SAMe Rx-Mood (Nature's Plus)
SAMe Rx-Mood (Nature's Plus) - General Information
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
Pharmacology of SAMe Rx-Mood (Nature's Plus)
S-adenosylmethionine is an intermediate metabolite of methionine.Its involvement in methylation assists in cellular growth and repair, maintains the phospho-bilipid layer in cell membranes. It also helps in the maintenance of the action of several hormones and neurotransmitters that affect mood. Highest concentration are found in the brain and the liver.
SAMe Rx-Mood (Nature's Plus) for patients
Sufferers of bipolar disorder (manic-depressive illness) should not use SAMe unless under medical supervision. Those who are taking anti-depressant medications should confer with their physicians before taking SAMe in place of or in addition to those medications. They should continue to be monitored by their physician. SAMe is not recommended for use in children. It should only be used by pregnant women with a physician's approval and under a physician's supervision. Nursing mothers should avoid SAMe supplementation.
There is no evidence that SAMe is either mutagenic or carcinogenic. But since nucleic acid methylation patterns may change in those with cancer, the use of SAMe by cancer patients should be discussed with their physicians. SAMe may one day be shown to be effective in preventing and possibly even treating some forms of cancer but, in the meantime, because it is an active methylating agent, some caution is advised in those who have cancer.
Those undergoing gene therapy should avoid supplemental SAMe.
SAMe Rx-Mood (Nature's Plus) Interactions
There are so far no reported adverse interactions with SAMe and other drugs, dietary supplements or foods.
SAMe Rx-Mood (Nature's Plus) Contraindications
No known contraindications.
Additional information about SAMe Rx-Mood (Nature's Plus)
SAMe Rx-Mood (Nature's Plus) Indication: SAMe Rx-Mood (Nature's Plus) (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.
Mechanism Of Action: SAMe Rx-Mood (Nature's Plus) (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: S-Adenosylmethionine
Synonyms: SAM-e; Acylcarnitine; S-Adenosyl-L-methionine; SAM; AdoMet
Drug Category: Dietary supplement; Micronutrient
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing S-Adenosylmethionine: SAMe Rx-Mood (Nature's Plus); Sam-Sulfate (Natrol);
Absorption: S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake.
Toxicity (Overdose): Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression.
Protein Binding: Not Available
Biotransformation: Significant first-pass metabolism in the liver. Approximately 50% of S-Adenosylmethionine (SAMe) is metabolized in the liver. SAMe is metabolized to S-adenosylhomocysteine, which is then metabolized to homocysteine. Homocysteine can either be metabolized to cystathionine and then cysteine or to methionine. The cofactor in the metabolism of homocysteine to cysteine is vitamin B6. Cofactors for the metabolism of homocysteine to methionine are folic acid, vitamin B12 and betaine.
Half Life: Not Available
Dosage Forms of SAMe Rx-Mood (Nature's Plus): Capsule Oral
Capsule Oral
Capsule Oral
Capsule, delayed release Oral
Tablet Oral
Tablet Oral
Chemical IUPAC Name: [(3S)-3-amino-4-hydroxy-4-oxobutyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium
Chemical Formula: C15H23N6O5S+
S-Adenosylmethionine on Wikipedia: https://en.wikipedia.org/wiki/S-Adenosylmethionine
Organisms Affected: Humans and other mammals
